USMLE Step 1 practice questions by topic

Browse sample questions with full explanations from every content area on the real Step 1 blueprint.

Cardiovascular System

Heart failure, valvular disease, arrhythmias, congenital defects, and the pharmacology that goes with them.

101 practice questions

Respiratory & Renal/Urinary Systems

Acid-base physiology, glomerular disease, COPD/asthma, and the renal and pulmonary topics tested together.

135 practice questions

Gastrointestinal System

Liver disease, malabsorption, GI bleeding, and the anatomy/embryology that underlies GI pathology.

96 practice questions

Reproductive & Endocrine Systems

Thyroid, adrenal, and pituitary axes, pregnancy physiology, and reproductive pathology.

147 practice questions

Behavioral Health & Nervous Systems/Special Senses

Neuroanatomy, psychiatric disorders, pharmacology of the CNS, and the special senses.

132 practice questions

Musculoskeletal, Skin & Subcutaneous Tissue

Rheumatologic disease, bone/joint pathology, and dermatologic conditions.

111 practice questions

Blood & Lymphoreticular/Immune Systems

Anemias, coagulation disorders, leukemias/lymphomas, and immunology.

114 practice questions

Multisystem Processes & Disorders

Genetic syndromes, toxicology, and disease processes that cut across organ systems.

106 practice questions

Biostatistics & Epidemiology/Population Health

Study design, test characteristics, bias, and the statistics questions every Step 1 taker dreads.

64 practice questions

Social Sciences: Communication and Interpersonal Skills

Ethics, patient communication, and the professionalism scenarios on every exam.

79 practice questions

Human Development

Embryology, developmental milestones, and the physiology of pregnancy and the newborn.

38 practice questions