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USMLE Step 1 Gastrointestinal System practice questions

Liver disease, malabsorption, GI bleeding, and the anatomy/embryology that underlies GI pathology. This category has 96 original questions in the full StepExamPrep bank — here are 3 samples with complete explanations.

Sample question 1

Which of the following is the most common location for gastrointestinal carcinoid (neuroendocrine) tumors?

A. Esophagus
B. Appendix and small bowel Correct
C. Stomach exclusively
D. Rectum exclusively, with no other common sites
E. Gallbladder
Explanation:

The appendix and small bowel (particularly the ileum) are among the most common sites for gastrointestinal carcinoid tumors, arising from neuroendocrine cells.

Sample question 2

A patient with a posterior duodenal ulcer develops sudden severe back pain and a drop in hemoglobin. Which of the following structures is most likely eroded, causing this presentation?

A. Splenic artery
B. Gastroduodenal artery Correct
C. Superior mesenteric artery
D. Portal vein
E. Left gastric artery
Explanation:

Posterior duodenal ulcers classically erode into the gastroduodenal artery, which runs immediately posterior to the first part of the duodenum, causing brisk, potentially life-threatening hemorrhage.

Sample question 3

Which of the following is the strongest modifiable risk factor for pancreatic adenocarcinoma?

A. Blood type
B. Cigarette smoking Correct
C. Height
D. Eye color
E. Hair color
Explanation:

Cigarette smoking is the strongest well-established modifiable risk factor for pancreatic adenocarcinoma, roughly doubling risk in smokers.

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