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USMLE Step 1 Respiratory & Renal/Urinary Systems practice questions

Acid-base physiology, glomerular disease, COPD/asthma, and the renal and pulmonary topics tested together. This category has 135 original questions in the full StepExamPrep bank — here are 3 samples with complete explanations.

Sample question 1

A patient on mechanical ventilation for ARDS is managed with a lung-protective strategy using low tidal volumes. Which of the following best explains the rationale for this approach?

A. Low tidal volumes reduce ventilator-induced lung injury from overdistension of already-damaged alveoli Correct
B. Low tidal volumes have no effect on outcomes
C. High tidal volumes are always preferred regardless of underlying lung condition
D. Low tidal volumes eliminate the need for any oxygen supplementation
E. Low tidal volumes are used exclusively to reduce cost
Explanation:

In ARDS, much of the lung is already damaged/non-aerated; using low tidal volumes helps avoid overdistension (volutrauma) of the remaining functional alveoli, reducing ventilator-induced lung injury and improving outcomes — a well-established evidence-based strategy.

Sample question 2

A sexually active 24-year-old woman presents with dysuria, urinary frequency, and suprapubic pain without fever or flank pain. Which of the following is the most likely causative organism?

A. Escherichia coli Correct
B. Pseudomonas aeruginosa
C. Candida albicans
D. Mycoplasma genitalium
E. Trichomonas vaginalis
Explanation:

E. coli is by far the most common cause of uncomplicated cystitis in young sexually active women.

Sample question 3

A pleural fluid sample has a pleural fluid-to-serum protein ratio of 0.6. According to Light's criteria, how should this fluid be classified?

A. Transudate
B. Exudate Correct
C. Cannot be determined without LDH values
D. Chylothorax
E. Hemothorax
Explanation:

Light's criteria classify a pleural effusion as an exudate if the pleural-to-serum protein ratio exceeds 0.5 (among other criteria); a ratio of 0.6 meets this threshold, classifying it as an exudate.

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