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USMLE Step 1 Reproductive & Endocrine Systems practice questions

Thyroid, adrenal, and pituitary axes, pregnancy physiology, and reproductive pathology. This category has 147 original questions in the full StepExamPrep bank — here are 3 samples with complete explanations.

Sample question 1

Which of the following medications works by inhibiting osteoclast-mediated bone resorption through binding to hydroxyapatite in bone?

A. Teriparatide
B. Bisphosphonates Correct
C. Denosumab
D. Raloxifene
E. Calcitonin
Explanation:

Bisphosphonates bind to hydroxyapatite in bone and are taken up by osteoclasts during resorption, inhibiting their function and inducing apoptosis, reducing bone resorption.

Sample question 2

A woman at risk for preterm delivery at 28 weeks gestation is given a course of antenatal corticosteroids. Which of the following best explains the purpose of this intervention?

A. To treat maternal hypertension
B. To accelerate fetal lung maturity by stimulating surfactant production, reducing risk of neonatal respiratory distress syndrome Correct
C. To induce labor immediately
D. To treat a maternal infection
E. To reduce fetal heart rate
Explanation:

Antenatal corticosteroids accelerate fetal lung maturation by stimulating type II pneumocyte surfactant production, significantly reducing the risk and severity of neonatal respiratory distress syndrome if preterm delivery occurs.

Sample question 3

A 25-year-old man has a painless testicular mass. Serum AFP is markedly elevated, while beta-hCG is normal. Which of the following is the most likely diagnosis?

A. Seminoma
B. Yolk sac tumor Correct
C. Choriocarcinoma
D. Leydig cell tumor
E. Epididymitis
Explanation:

Yolk sac tumor is the classic AFP-producing testicular germ cell tumor, and is actually the most common testicular tumor in young children as well.

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