Rheumatologic disease, bone/joint pathology, and dermatologic conditions. This category has 111 original questions in the full StepExamPrep bank — here are 3 samples with complete explanations.
Which of the following is the single most important prognostic factor for cutaneous melanoma?
Breslow depth (the measured vertical thickness of tumor invasion) is the single most important prognostic factor for cutaneous melanoma, directly correlating with metastatic risk and used centrally in staging.
A sexually active young adult has an acutely swollen, painful knee. Synovial fluid analysis shows a WBC count of 60,000/uL with predominantly neutrophils. Which of the following is the most likely causative organism?
While gonococcal arthritis is an important consideration in sexually active young adults, S. aureus remains the single MOST COMMON cause of septic (bacterial) arthritis overall across age groups.
A 4-year-old boy has calf enlargement, difficulty climbing stairs, and uses his hands to push up from the floor to standing. Creatine kinase is markedly elevated. Which of the following best describes the molecular defect?
This presentation (Gowers sign, calf pseudohypertrophy, markedly elevated CK, early childhood onset) is Duchenne muscular dystrophy, caused by a frameshift mutation resulting in absent dystrophin protein.
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