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USMLE Step 1 Human Development practice questions

Embryology, developmental milestones, and the physiology of pregnancy and the newborn. This category has 38 original questions in the full StepExamPrep bank — here are 3 samples with complete explanations.

Sample question 1

Which of the following is typically the first physical sign of puberty in girls?

A. Menarche
B. Breast budding (thelarche) Correct
C. Pubic hair growth as the very first sign in all cases
D. Growth spurt as the first sign in all cases
E. Voice deepening
Explanation:

Breast budding (thelarche) is typically the first physical sign of puberty in girls, usually preceding pubic hair development and the growth spurt.

Sample question 2

Researchers compare concordance rates for a disease between monozygotic and dizygotic twins to estimate the relative contribution of genetics versus environment. Which of the following findings would suggest a strong genetic component?

A. Equal concordance rates in monozygotic and dizygotic twins
B. Significantly higher concordance rate in monozygotic twins compared to dizygotic twins Correct
C. Zero concordance in both twin types
D. Higher concordance in dizygotic twins compared to monozygotic twins
E. Twin studies provide no information about genetic contribution
Explanation:

Since monozygotic twins share (nearly) 100% of their genes while dizygotic twins share on average 50%, a significantly HIGHER concordance rate in monozygotic twins suggests a stronger genetic contribution to the disease.

Sample question 3

A 4-year-old insists on choosing his own clothes and becomes upset when his parents intervene, showing a strong desire to initiate activities on his own. According to Erikson, which developmental stage is this?

A. Trust vs. mistrust
B. Autonomy vs. shame and doubt
C. Initiative vs. guilt Correct
D. Industry vs. inferiority
E. Identity vs. role confusion
Explanation:

Initiative vs. guilt is the preschool stage (ages ~3-6), characterized by a desire to initiate activities and assert control, matching this child's behavior.

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